Dendritic Compartmentalization of Learning-Related Plasticity

L Godenzini; AS Shai; LM Palmer

Journal article

Dendritic Compartmentalization of Learning-Related Plasticity

L Godenzini, AS Shai, LM Palmer

Eneuro | Published : 2022

DOI: 10.1523/ENEURO.0060-22.2022

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Abstract

The dendrites of cortical pyramidal neurons receive synaptic inputs from different pathways that are organized according to their laminar target. This architectural scheme provides cortical neurons with a spatial mechanism to separate information, which may support neural flexibility required during learning. Here, we investigated layer-specific plasticity of sensory encoding following learning by recording from two different dendritic com-partments, tuft and basal dendrites, of layer 2/3 (L2/3) pyramidal neurons in the auditory cortex of mice. Following auditory fear conditioning, auditory-evoked Ca21 responses were enhanced in tuft, but not basal, dendrites leading to increased somatic act..

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University of Melbourne Researchers

Lucy Palmer Author

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Grants

Awarded by Sylvia and Charles Viertel Charitable Foundation

Funding Acknowledgements

This work was supported by the National Health and Medical Research Council Grants APP1086082, APP1063533, and APP1085708, the Australian Research Council Grant DP160103047, and the Sylvia and Charles Viertel Charitable Foundation.