Dendritic Compartmentalization of Learning-Related Plasticity

L Godenzini; AS Shai; LM Palmer

Journal article

Dendritic Compartmentalization of Learning-Related Plasticity

L Godenzini, AS Shai, LM Palmer

Eneuro | Published : 2022

DOI: 10.1523/ENEURO.0060-22.2022

Open access

Download PDF

Abstract

The dendrites of cortical pyramidal neurons receive synaptic inputs from different pathways that are organized according to their laminar target. This architectural scheme provides cortical neurons with a spatial mechanism to separate information, which may support neural flexibility required during learning. Here, we investigated layer-specific plasticity of sensory encoding following learning by recording from two different dendritic com-partments, tuft and basal dendrites, of layer 2/3 (L2/3) pyramidal neurons in the auditory cortex of mice. Following auditory fear conditioning, auditory-evoked Ca21 responses were enhanced in tuft, but not basal, dendrites leading to increased somatic act..

View full abstract

University of Melbourne Researchers

Lucy Palmer Author

Related Projects (4)

THE FUNCTION AND MODULATION OF BRAIN CELLS DURING SENSORY PROCESSING

Understanding how brain cells translate sensory input into behaviour is central to explaining how the brain works. My research focuses on th..

THE MODULATION OF NEURONAL ACTIVITY BY INTER-CORTICAL SENSORY INPUT

For any given behaviour, the brain must merge information from all different sensory systems to generate a coherent representation of the ex..

DENDRITIC ACTIVITY AND NEURONAL OUTPUT DURING SENSORY PERCEPTION

A fundamental goal of neuroscience is to understand how sensory experiences arise from activity in the brain. This is no easy feat and is th..

The processing of sensory information within cortical circuits

This project aims to improve our knowledge of neuronal activity during sensory perception and therefore shed light on overall brain function..

Grants

Awarded by Sylvia and Charles Viertel Charitable Foundation

Funding Acknowledgements

This work was supported by the National Health and Medical Research Council Grants APP1086082, APP1063533, and APP1085708, the Australian Research Council Grant DP160103047, and the Sylvia and Charles Viertel Charitable Foundation.